cobra 120 mg tablet - Genel Bakış
cobra 120 mg tablet - Genel Bakış
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Penile erection is a very complex physiological process. Erection problems occur for a variety of reasons, but they are usually associated with arterial or venous insufficiency.
The mean steady-state volume of distribution documented for sildenafil is approximately 105 L - a value which suggests the medication undergoes distribution into the tissues .
With reduced sensitivity to Sildenafil, the drug may not work the first time, stable therapeutic results may appear after using 5 doses;
During pregnancy, sildenafil should be used only when clearly needed. Since high blood pressure in the lungs is a serious condition that dirilik harm both a pregnant woman and her unborn baby, do not stop this medication unless directed by your doctor.
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Sexual activity may put extra strain on your heart, especially if you have heart problems. If you have heart problems and experience any of these serious side effects while having sex, stop and get medical help right away: severe burayı kontrol et dizziness, fainting, chest/jaw/left arm pain, nausea.
When sexual stimulation causes local daha fazla bilgi al release of NO, inhibition of PDE-5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Cobra at recommended doses özgü no effect in the absence of sexual stimulation.
A feature of the general Sildenafil action: a pronounced effect Daha fazla bilgi on the vessels in the lungs and pelvic organs. The drug does provides no significant effect over the blood circulation of the body.
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Regardless, the extent of absorption is hamiş observed to be significantly affected birli the recorded AUC decreased by only about 11 % .
When the NO/cGMP pathway is activated, kakım occurs with sexual stimulation, inhibition of PDE5 by sildenafil results in increased corpus cavernosum levels of cGMP . Therefore sexual stimulation is required in order for sildenafil to produce its intended beneficial pharmacological effects .
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